Katherine won an Emmy for Grey’s Anatomy in 2007 and was slated to be in the race again for the 2008 Awards, but she withdrew her name because she felt that the show’s most recent 4th season (which was affected by a writer’s strike and was not considered the best season of the series) "didn’t give her the material" to rightfully be up as an Emmy candidate. Katherine received a lot of heat from the media by criticizing the writers who were involved with Season 4.

When Katherine appeared on the Ellen Degeneres Show in 2007, shortly before Knocked Up was released, she wore a white blouse and skirt with a belt, an outfit that flaunted her very thin frame. Some may notice that she was walking funny when she came out, and when she sat down with Ellen, she joked that she bought the outfit because she loved it so much, but she didn’t test it beforehand to see if it was comfortable to sit in, so when she tried crossing her legs, it produced very awkward results on live television.

Judd Apatow, who directed the 2007 comedy Knocked Up, says that Katherine was chosen for the lead role because she seemed like the only actress who would be believable as a person who actually liked Seth Rogan’s ruggedy, immature, teddy-bear-like character.

Katherine was nominated in 2008 for a SAG Award along with her Grey’s Anatomy castmates for Outstanding Performanace by an Ensemble in a Drama Series.

Katherine made headlines in 2008 by criticizing some elements of her 2007 film Knocked Up, which helped catapult her to superstardom. Katherine believes that the women in the movie were portrayed as "humorless shrews."

Katherine received her Knocked Up role after Anne Hathaway dropped out.

Katherine’s honeymoon got off to a bumby start when she forgot her passport. The couple had to stop over in California, instead of going directly to Cabo.

Katherine’s co-stars from Grey’s Anatomy that attended her wedding were T.R. Knight, Sandra Oh, and Kate Walsh.

Katherine’s best man in her wedding was her Grey’s Anatomy co-star T.R. Knight.

Katherine married musician Josh Kelley in Park City ceremony witnessed by her Grey’s Anatomy co-stars.

On December 13, 2007, Katherine Heigl was nominated for a Golden Globe Award in the "Actress In A Supporting Role – Series, Mini-Series Or Television Movie" category for her performance in Grey’s Anatomy.

Katherine was ranked #12 on Entertainment Tonight’s "Hot List of 2007".

Katherine was ranked #32 in FHM Online’s 100 Sexiest Women in the World of 2007.

Katherine ranked #14 in Maxim’s 2007 Hot 100 List.

Katherine participated in the picketers’ line in the 2007 Writers Guild Of America’s strike.

Katherine has said that filming the birthing scenes in the 2007 film Knocked Up helped seal her decision to adopt children, rather than conceive on her own. "It doesn’t sound like any fun to me," she says.

Katherine received the role of Alison in Knocked Up after actress Anne Hathaway, who was originally offered the part, backed out due to the graphic birthing scenes.

Katherine won an Emmy Award in 2007, for her performance on Grey’s Anatomy.

In Wish Upon a Star, Katherine is more than a year younger than Danielle Harris, who plays her younger sister in the movie.

In June 2007, Katherine launched her own line of hospital scrubs and hospital gear from the Katherine Heigl Collection. Katherine collaborated with a health-care clothing company to design the line.

Katherine was chosen as one of People Magazine’s annual 100 Most Beautiful People in May 2007.

Katherine says that T.R. Knight (co-star on Grey’s Anatomy) is her best friend in real life. She even had him stand up as one of her "bridesmaids" in her wedding.

When Katherine had to do her first underwear scene in Grey’s Anatomy she felt very uncomfortable. She jokingly asked the director to strip down as well, and he obliged!

Katherine’s favorite movie is The 40 Year Old Virgin, which she watches over and over again.

Katherine says that her Grey’s Anatomy co-star Justin Chambers is like a brother to her. The whole crew has become her family.

Katherine enjoys relaxing, sitting on one of her big couches with her dogs, reading, knitting, or going to the movies or bar with her fiance.

Katherine was honored by Cosmopolitan magazine and had dinner with the magazine’s editor, Kate White, to celebrate her appearance on the cover of Cosmopolitan’s December 2006 issue.

Katherine’s fiancé, singer Josh Kelley, proposed to her in June 2006 with a three-carat pear-shaped diamond engagement ring. Josh and Katherine met on the set of his music video for the song ‘Only You,’ which Katherine appeared in. The pair is planning a "Winter Wonderland" themed wedding.

Katherine won in 2003 together with the crew of Love Comes Softly the Camie award (Character and Morality in Entertainment Awards). She also won it for the movie Love’s Enduring Promise in 2005, again together with the crew.

Katherine was nominated for a Golden Globe in December of 2006 in the category of Best Performance by a Supporting Actress in a Television Series, for her role in Grey’s Anatomy.

Katherine was named #19 in FHM magazine’s "100 Sexiest Women in the World 2006" supplement.

Katherine was ranked #55 in FHM’s "100 Sexiest Women in the World" list for 2005.

Rather than see a stylist, Katherine cut and dyed her own hair for the third season of Roswell.

She has two miniature schnauzers named Anna and Romeo.

In 2002 Stuff Magazine named Katherine the 72nd in the "102 Sexiest Women In The World" Edition.

During high school, Katherine played the cello.

Katherine’s brother Jason died when she was young, due to head injuries sustained in a car accident.

Katherine beat out Alicia Silverstone for the lead role in My Father the Hero.

Katherine graduated from New Canaan High School in 1996.

She began dating Joseph Lawrence in 1994. They met at Seventeen Magazine’s 50th Anniversary party.

Katherine is half Irish and half German.

Katherine auditioned for all three female leads on Roswell (Isabel, Maria, and Liz) before she was cast as Isabel.

Katherine has two older brothers named Holt and Jason. She also has an older sister named Meg.

Katherine is a former client of the Elite Modelling Agency.

Katherine is 5′ 9" tall.

Katherine was honored by the National Coalition on Donation Awards in July 2005 in Los Angeles. She received the James S. Wolf Courage Award for educating the public about organ donation.

Katherine was once engaged to Jason Behr, her former Roswell co-star. They broke up in 2001.

Katherine has played three separate characters with the same name (although one time, it had a slightly different spelling). In Roswell, she was Isabel Evans. In Wuthering Heights, she played an Isabel once again. In Grey’s Anatomy, she plays Isobel.